As described in Sophos Anti-Virus for Windows 2000+: removing W32/Confick and Mal/Conficker, Conficker is a virus that spreads through infected Windows shared folders and USB storage devices.
The Sophos Conficker Cleanup Tool (network version) is a powerful solution for eliminating Conficker infections. It allows you to Detect, isolate, and remove the Conficker virus on your network.
Note: If you need to remove Conficker from computers that are not in a network, use the Sophos Conficker Cleanup Tool (standalone version).
If you are running Sophos Anti-Virus you do not need to disable HIPs while you're using the Sophos Conficker Cleanup Tool. Whilst this tool should not conflict with other anti-virus products, the nature of the tool means it may be blocked by behaviour-based (HIPS) functionality within non-Sophos anti-virus solutions.